What is PsA?

What is PsA?

Psoriatic arthritis [pronounced sorr-eye-at-ick arth-rye-tis], also called PsA, is a chronic, or ongoing, immune-mediated (caused by the immune system*) inflammatory disease that affects the joints.1

                  In PsA, the body’s immune system attacks its own joints1

                  In people with PsA, the immune system targeting its own joints causes pain, swelling, fatigue and stiffness in the joints, which may restrict your movement and make it difficult to do simple things.1 PsA can affect many joints in the body or only a few – it’s different for everyone and can change over time.1,2 People with PsA may also have skin psoriasis.3

                  How psoriatic arthritis affects the body4

                  How psoriatic arthritis affects the body4

                  About 85% of people with PsA also have skin psoriasis, but they don’t always develop at the same time5,6

                  Neither PsA nor psoriasis (PsO) is contagious,7,8 but it can mean that you stand a greater risk of developing some other disease, such as diabetes, cardiovascular disease, inflammatory intestinal disease, auto-immune eye disease, fibromyalgia or depression.9

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                  The immune system is a complex set of cells and molecules designed to defend the body against foreign substances including cancer cells, toxins and parasites. When the system turns towards body (so-called `self`) components, immune-mediated inflammatory diseases occur. Examples of these are rheumatoid arthritis, psoriasis, psoriatic arthritis and multiple sclerosis.10

                  1. National Psoriasis Foundation. About psoriatic arthritis. Available at: https://www.psoriasis.org/about-psoriatic-arthritis. Accessed: October 2021.
                  2. Creakyjoints. Psoriatic arthritis flare-ups. Available at: https://creakyjoints.org/living-with-arthritis/psoriatic-arthritis-flare-ups. Accessed: October 2021.
                  3. Bagel J and Schwartzman S. Am J Clin Dermatol 2018;19:839-852.
                  4. WebMD. How does psoriatic arthritis affect your body? Available at: https://www.webmd.com/arthritis/psoriatic-arthritis/ss/slideshow-psoriatic-arthritis-body. Accessed: October 2021.
                  5. Coates LC and Helliwell PS. Clin Med 2017: 17(1):65-70.
                  6. Ritchlin CT, et al. N Engl J Med 2017;376:957-970. ?
                  7. PAPAA. Psoriasis: a simple explanation. Available at: https://www.papaa.org/learn-about-psoriasis-and-psoriatic-arthritis/common-questions/psoriasis-a-simple-explanation. Accessed: October 2021.
                  8. Arthritis Foundation. Psoriatic arthritis. Available at: https://www.arthritis.org/diseases/psoriatic-arthritis. Accessed: October 2021.
                  9. Haddad A, et al. Rambam Maimonides Med J 2017;8(1:e0004): 1-6.
                  10. British Society of Immunology. What is immunology? Available at: https://www.immunology.org/public-information/what-is-immunology. Accessed: October 2021.
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